Novel multifunctional drug D-264 for Parkinson’s disease: Evidence of neuroprotective property in PD animal models induced by MPTP and lactacystin
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چکیده
REFERENCES METHODS D-264 treatment partially rescued the loss of dopaminergic neurons in SN, inhibited the activation of microglia, and improve the impairment of behaviour caused by MPTP and lactacystin in pole and rotarod tests (data not shown here). The neuroprotective effects of D-264 shown in the present study may partly due to the upregulation of both BDNF and GDNF and the restoration of proteasomal activity . As a drug used in the clinic for other indications, we proposed that further studies on D-264 should be conducted in order to consider it as a novel therapy for PD. LEGENDS
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تاریخ انتشار 2009